A research team at Israel’s Bar-Ilan University has developed a breakthrough way to fight wrinkles and other signs of aging without the use of injections. The team of researchers created a cream that contains small molecules of hyaluronic acid (HA) polymers, which help fight the signs of aging.

The research project was sponsored by the Israeli cosmeceutical company Hava Zingboim Ltd. Two professors from the university’s Chemistry and Physics Departments and Institute for Nanotechnology and Advanced Materials, Rachel Lubart and Aharon Gedanken, led the research team.

For the past 20 years, HA has been used in injection-based anti-aging treatments around the world. When the HA polymers are injected into the skin, they absorb liquids and neutralize toxins, so the wrinkles become blurred and the skin looks young and fresh.

Even through the human body naturally produces HA molecules, as a person ages, the amount of them his or her body produces diminishes. This is what makes a person look older. The HA molecules are rather large and thus injections have always been needed in order to get them to penetrate the skin.

However, the Israeli team was able to develop a simple and fast way to shrink the HA polymers, a process that was before believed to be costly and time-consuming. The Israeli breakthrough cream is expected to replace the use of facial injections in the anti-aging industry.

“All over the world, [people] are trying to micronize hyaluronic acid in order to use it as a cream so that there is an alternative to injections,” Lubart stated. “But at the moment, I’m not aware of anyone who has succeeded and we are the first to be able to say that we succeeded.”